Difference in EGFR expression and mean vascular density in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma

Alejandra Fernández, Javier Fernández, Maureen Marshall, René Martínez, Sven Niklander, Ziyad S. Haidar

Resultado de la investigación: Research - revisión exhaustivaArticle

Resumen

To evaluate the expression of the epidermal growth factor receptor (EGFR) and mean vascular density (MVD) in normal oral mucosa (NOM), oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). Material and methods: Descriptive case study. Nineteen histological samples diagnosed with NOM, 18 diagnosed with OED, and 19 with OSCC, were analyzed with immunohistochemistry against EGFR and CD31. EGFR expression was evaluated by extent and intensity of its expression in normal, dysplastic and neoplastic epithelium. MVD was determined through the detection of blood vessels by antibodies against CD31. Results: Extension of EGFR expression was highest in OSCC followed by OED and lowest in NOM, resulting in significant different between the degrees of extension (p<0.001). Intensity of EGFR was similar in NOM, OED and OSCC, without differences in its expression (p=0.533). Differences in MVD were found between NOM and OSCC groups (p<0.01), and between OED and OSCC groups (p<0.01), with no differences between NOM and OED groups (p=0.91). MVD was 21.17±4.98 in NOM, 23.40±5.77 in OED and 33.92±8.39 in OSCC. Conclusion: EGFR is expressed in normal, dysplastic or neoplastic oral epithelium. However, the extent of its expression is greater as malignancy increases. MVD varies according to the diagnosis.

IdiomaEnglish
Páginas39-45
Número de páginas7
PublicaciónJournal of Oral Research
Volumen6
Número de edición2
DOI
EstadoPublished - 2017

Huella dactilar

Mouth Mucosa
Epidermal Growth Factor Receptor
Blood Vessels
Squamous Cell Carcinoma
Epithelium
Immunohistochemistry
Antibodies
Neoplasms

Keywords

    ASJC Scopus subject areas

    • Dentistry(all)

    Citar esto

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    title = "Difference in EGFR expression and mean vascular density in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma",
    abstract = "To evaluate the expression of the epidermal growth factor receptor (EGFR) and mean vascular density (MVD) in normal oral mucosa (NOM), oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). Material and methods: Descriptive case study. Nineteen histological samples diagnosed with NOM, 18 diagnosed with OED, and 19 with OSCC, were analyzed with immunohistochemistry against EGFR and CD31. EGFR expression was evaluated by extent and intensity of its expression in normal, dysplastic and neoplastic epithelium. MVD was determined through the detection of blood vessels by antibodies against CD31. Results: Extension of EGFR expression was highest in OSCC followed by OED and lowest in NOM, resulting in significant different between the degrees of extension (p<0.001). Intensity of EGFR was similar in NOM, OED and OSCC, without differences in its expression (p=0.533). Differences in MVD were found between NOM and OSCC groups (p<0.01), and between OED and OSCC groups (p<0.01), with no differences between NOM and OED groups (p=0.91). MVD was 21.17±4.98 in NOM, 23.40±5.77 in OED and 33.92±8.39 in OSCC. Conclusion: EGFR is expressed in normal, dysplastic or neoplastic oral epithelium. However, the extent of its expression is greater as malignancy increases. MVD varies according to the diagnosis.",
    keywords = "Epidermal growth factor receptor, Mouth neoplasms, Oral cavity, Pathologic angiogenesis",
    author = "Alejandra Fernández and Javier Fernández and Maureen Marshall and René Martínez and Sven Niklander and Haidar, {Ziyad S.}",
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    Difference in EGFR expression and mean vascular density in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma. / Fernández, Alejandra; Fernández, Javier; Marshall, Maureen; Martínez, René; Niklander, Sven; Haidar, Ziyad S.

    En: Journal of Oral Research, Vol. 6, N.º 2, 2017, p. 39-45.

    Resultado de la investigación: Research - revisión exhaustivaArticle

    TY - JOUR

    T1 - Difference in EGFR expression and mean vascular density in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma

    AU - Fernández,Alejandra

    AU - Fernández,Javier

    AU - Marshall,Maureen

    AU - Martínez,René

    AU - Niklander,Sven

    AU - Haidar,Ziyad S.

    PY - 2017

    Y1 - 2017

    N2 - To evaluate the expression of the epidermal growth factor receptor (EGFR) and mean vascular density (MVD) in normal oral mucosa (NOM), oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). Material and methods: Descriptive case study. Nineteen histological samples diagnosed with NOM, 18 diagnosed with OED, and 19 with OSCC, were analyzed with immunohistochemistry against EGFR and CD31. EGFR expression was evaluated by extent and intensity of its expression in normal, dysplastic and neoplastic epithelium. MVD was determined through the detection of blood vessels by antibodies against CD31. Results: Extension of EGFR expression was highest in OSCC followed by OED and lowest in NOM, resulting in significant different between the degrees of extension (p<0.001). Intensity of EGFR was similar in NOM, OED and OSCC, without differences in its expression (p=0.533). Differences in MVD were found between NOM and OSCC groups (p<0.01), and between OED and OSCC groups (p<0.01), with no differences between NOM and OED groups (p=0.91). MVD was 21.17±4.98 in NOM, 23.40±5.77 in OED and 33.92±8.39 in OSCC. Conclusion: EGFR is expressed in normal, dysplastic or neoplastic oral epithelium. However, the extent of its expression is greater as malignancy increases. MVD varies according to the diagnosis.

    AB - To evaluate the expression of the epidermal growth factor receptor (EGFR) and mean vascular density (MVD) in normal oral mucosa (NOM), oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). Material and methods: Descriptive case study. Nineteen histological samples diagnosed with NOM, 18 diagnosed with OED, and 19 with OSCC, were analyzed with immunohistochemistry against EGFR and CD31. EGFR expression was evaluated by extent and intensity of its expression in normal, dysplastic and neoplastic epithelium. MVD was determined through the detection of blood vessels by antibodies against CD31. Results: Extension of EGFR expression was highest in OSCC followed by OED and lowest in NOM, resulting in significant different between the degrees of extension (p<0.001). Intensity of EGFR was similar in NOM, OED and OSCC, without differences in its expression (p=0.533). Differences in MVD were found between NOM and OSCC groups (p<0.01), and between OED and OSCC groups (p<0.01), with no differences between NOM and OED groups (p=0.91). MVD was 21.17±4.98 in NOM, 23.40±5.77 in OED and 33.92±8.39 in OSCC. Conclusion: EGFR is expressed in normal, dysplastic or neoplastic oral epithelium. However, the extent of its expression is greater as malignancy increases. MVD varies according to the diagnosis.

    KW - Epidermal growth factor receptor

    KW - Mouth neoplasms

    KW - Oral cavity

    KW - Pathologic angiogenesis

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    U2 - 10.17126/joralres.2017.016

    DO - 10.17126/joralres.2017.016

    M3 - Article

    VL - 6

    SP - 39

    EP - 45

    JO - Journal of Oral Research

    T2 - Journal of Oral Research

    JF - Journal of Oral Research

    SN - 0719-2479

    IS - 2

    ER -