Individual subject meta-analysis of parameters for giardia duodenalis shedding in animal experimental models

A. D. Adell, W. A. Miller, D. J. Harvey, E. Van Wormer, S. Wuertz, P. A. Conrad

Resultado de la investigación: Contribución a la publicaciónArticle

  • 2 Citas

Resumen

Giardia duodenalis is a zoonotic protozoan parasite with public health importance worldwide. While articles about animal model infectivity have been published for G. duodenalis, the studies have used diverse protocols and parameters to evaluate the infectivity of this protozoan parasite. Hence, the objectives of this study were to (1) conduct a meta-analysis of published literature for cyst shedding and diarrhea outcomes in animal models and (2) develop recommendations to help standardize experimental dose response studies. Results showed that, for the outcome of cyst shedding in faeces, the covariates of infective stage (cyst versus trophozoite), Giardia dose, and the interactions between doses and infective stage, as well as dose and species of experimental host, were all significant (P value ≤ 0.05). This study suggests inoculation of the experimental host with cysts rather than trophozoites and administration of higher doses of Giardia will most likely result in cyst shedding. Based on the results of this meta-analysis, the infective stage (cyst versus trophozoite), parasite dose, and the interactions between dose and infective stage, as well as dose and species of experimental host, should be considered when designing experimental dose response studies that will assist in the study of zoonotic neglected tropical diseases globally.

Idioma originalEnglish
Número de artículo476142
PublicaciónBioMed Research International
Volumen2014
Identificadores de objetos digitales
EstadoPublished - 2014

Huella dactilar

Giardia lamblia
Meta-Analysis
Cysts
Anthralin
Porphobilinogen Synthase
Parasites
Giardia
Zoonoses
Supravalvular Aortic Stenosis
Tacrine
Neglected Diseases
Feces
Diarrhea
Public Health

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Citar esto

Adell, A. D.; Miller, W. A.; Harvey, D. J.; Van Wormer, E.; Wuertz, S.; Conrad, P. A. / Individual subject meta-analysis of parameters for giardia duodenalis shedding in animal experimental models.

En: BioMed Research International, Vol. 2014, 476142, 2014.

Resultado de la investigación: Contribución a la publicaciónArticle

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abstract = "Giardia duodenalis is a zoonotic protozoan parasite with public health importance worldwide. While articles about animal model infectivity have been published for G. duodenalis, the studies have used diverse protocols and parameters to evaluate the infectivity of this protozoan parasite. Hence, the objectives of this study were to (1) conduct a meta-analysis of published literature for cyst shedding and diarrhea outcomes in animal models and (2) develop recommendations to help standardize experimental dose response studies. Results showed that, for the outcome of cyst shedding in faeces, the covariates of infective stage (cyst versus trophozoite), Giardia dose, and the interactions between doses and infective stage, as well as dose and species of experimental host, were all significant (P value ≤ 0.05). This study suggests inoculation of the experimental host with cysts rather than trophozoites and administration of higher doses of Giardia will most likely result in cyst shedding. Based on the results of this meta-analysis, the infective stage (cyst versus trophozoite), parasite dose, and the interactions between dose and infective stage, as well as dose and species of experimental host, should be considered when designing experimental dose response studies that will assist in the study of zoonotic neglected tropical diseases globally.",
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Individual subject meta-analysis of parameters for giardia duodenalis shedding in animal experimental models. / Adell, A. D.; Miller, W. A.; Harvey, D. J.; Van Wormer, E.; Wuertz, S.; Conrad, P. A.

En: BioMed Research International, Vol. 2014, 476142, 2014.

Resultado de la investigación: Contribución a la publicaciónArticle

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