Metal Nanoparticles as Targeted Carriers Circumventing the Blood–Brain Barrier

A. C. Sintov, C. Velasco-Aguirre, E. Gallardo-Toledo, E. Araya, M. J. Kogan

Resultado de la investigación: Research - revisión exhaustivaChapter

  • 3 Citas

Resumen

Metal nanoparticles have been proposed as a carrier and a therapeutic agent in biomedical field because of their unique physiochemical properties. Due to these physicochemical properties, they can be used in different fields of biomedicine. In relation to this, plasmonic nanoparticles can be used for detection and photothermal destruction of tumor cells or toxic protein aggregates, and magnetic iron nanoparticles can be used for imaging and for hyperthermia of tumor cells. In addition, both therapy and imaging can be combined in one nanoparticle system, in a process called theranostics. Metal nanoparticles can be synthesized to modulate their size and shape, and conjugated with different ligands, which allow their application in drug delivery, diagnostics, and treatment of central nervous system diseases. This review is focused on the potential applications of metal nanoparticles and their capability to circumvent the blood–brain barrier (BBB). Although many articles have demonstrated delivery of metal nanoparticles to the brain by crossing the BBB after systemic administration, the percentage of the injected dose that reaches this organ is low in comparison to others, especially the liver and spleen. In connection with this drawback, we elaborate the architecture of the BBB and review possible mechanisms to cross this barrier by engineered nanoparticles. The potential uses of metal nanoparticles for treatment of disorders as well as related neurotoxicological considerations are also discussed. Finally, we bring up for discussion a direct and relatively simpler solution to the problem. We discuss this in detail after having proposed the use of the intranasal administration route as a way to circumvent the BBB. This route has not been extensively studied yet for metal nanoparticles, although it could be used as a research tool for mechanistic understanding and toxicity as well as an added value for medical practice.

IdiomaEnglish
Título de la publicación alojadaNanotechnology and the Brain, 2016
EditorialAcademic Press Inc.
Páginas199-227
Número de páginas29
Volumen130
ISBN (versión impresa)9780128046364
DOI
EstadoPublished - 2016

Series de publicaciones

NombreInternational Review of Neurobiology
Volumen130
ISSN (impreso)00747742

Huella dactilar

Metal Nanoparticles
Blood-Brain Barrier
Nanoparticles
Therapeutics
Neoplasms
Intranasal Administration
Poisons
Central Nervous System Diseases
Fever
Spleen
Iron
Ligands
Liver
Brain
Research
Pharmaceutical Preparations
Protein Aggregates
Theranostic Nanomedicine

Keywords

    ASJC Scopus subject areas

    • Clinical Neurology
    • Cellular and Molecular Neuroscience

    Citar esto

    Sintov, A. C., Velasco-Aguirre, C., Gallardo-Toledo, E., Araya, E., & Kogan, M. J. (2016). Metal Nanoparticles as Targeted Carriers Circumventing the Blood–Brain Barrier. En Nanotechnology and the Brain, 2016 (Vol. 130, pp. 199-227). (International Review of Neurobiology; Vol. 130). Academic Press Inc.. DOI: 10.1016/bs.irn.2016.06.007
    Sintov, A. C. ; Velasco-Aguirre, C. ; Gallardo-Toledo, E. ; Araya, E. ; Kogan, M. J./ Metal Nanoparticles as Targeted Carriers Circumventing the Blood–Brain Barrier. Nanotechnology and the Brain, 2016. Vol. 130 Academic Press Inc., 2016. pp. 199-227 (International Review of Neurobiology).
    @inbook{2203c3dd0e3f484dbe85753c853f7aea,
    title = "Metal Nanoparticles as Targeted Carriers Circumventing the Blood–Brain Barrier",
    abstract = "Metal nanoparticles have been proposed as a carrier and a therapeutic agent in biomedical field because of their unique physiochemical properties. Due to these physicochemical properties, they can be used in different fields of biomedicine. In relation to this, plasmonic nanoparticles can be used for detection and photothermal destruction of tumor cells or toxic protein aggregates, and magnetic iron nanoparticles can be used for imaging and for hyperthermia of tumor cells. In addition, both therapy and imaging can be combined in one nanoparticle system, in a process called theranostics. Metal nanoparticles can be synthesized to modulate their size and shape, and conjugated with different ligands, which allow their application in drug delivery, diagnostics, and treatment of central nervous system diseases. This review is focused on the potential applications of metal nanoparticles and their capability to circumvent the blood–brain barrier (BBB). Although many articles have demonstrated delivery of metal nanoparticles to the brain by crossing the BBB after systemic administration, the percentage of the injected dose that reaches this organ is low in comparison to others, especially the liver and spleen. In connection with this drawback, we elaborate the architecture of the BBB and review possible mechanisms to cross this barrier by engineered nanoparticles. The potential uses of metal nanoparticles for treatment of disorders as well as related neurotoxicological considerations are also discussed. Finally, we bring up for discussion a direct and relatively simpler solution to the problem. We discuss this in detail after having proposed the use of the intranasal administration route as a way to circumvent the BBB. This route has not been extensively studied yet for metal nanoparticles, although it could be used as a research tool for mechanistic understanding and toxicity as well as an added value for medical practice.",
    keywords = "Gold nanoparticles, Intranasal route, Magnetic nanoparticles, Transcytosis",
    author = "Sintov, {A. C.} and C. Velasco-Aguirre and E. Gallardo-Toledo and E. Araya and Kogan, {M. J.}",
    year = "2016",
    doi = "10.1016/bs.irn.2016.06.007",
    isbn = "9780128046364",
    volume = "130",
    series = "International Review of Neurobiology",
    publisher = "Academic Press Inc.",
    pages = "199--227",
    booktitle = "Nanotechnology and the Brain, 2016",

    }

    Sintov, AC, Velasco-Aguirre, C, Gallardo-Toledo, E, Araya, E & Kogan, MJ 2016, Metal Nanoparticles as Targeted Carriers Circumventing the Blood–Brain Barrier. En Nanotechnology and the Brain, 2016. vol.. 130, International Review of Neurobiology, vol.. 130, Academic Press Inc., pp. 199-227. DOI: 10.1016/bs.irn.2016.06.007

    Metal Nanoparticles as Targeted Carriers Circumventing the Blood–Brain Barrier. / Sintov, A. C.; Velasco-Aguirre, C.; Gallardo-Toledo, E.; Araya, E.; Kogan, M. J.

    Nanotechnology and the Brain, 2016. Vol. 130 Academic Press Inc., 2016. p. 199-227 (International Review of Neurobiology; Vol. 130).

    Resultado de la investigación: Research - revisión exhaustivaChapter

    TY - CHAP

    T1 - Metal Nanoparticles as Targeted Carriers Circumventing the Blood–Brain Barrier

    AU - Sintov,A. C.

    AU - Velasco-Aguirre,C.

    AU - Gallardo-Toledo,E.

    AU - Araya,E.

    AU - Kogan,M. J.

    PY - 2016

    Y1 - 2016

    N2 - Metal nanoparticles have been proposed as a carrier and a therapeutic agent in biomedical field because of their unique physiochemical properties. Due to these physicochemical properties, they can be used in different fields of biomedicine. In relation to this, plasmonic nanoparticles can be used for detection and photothermal destruction of tumor cells or toxic protein aggregates, and magnetic iron nanoparticles can be used for imaging and for hyperthermia of tumor cells. In addition, both therapy and imaging can be combined in one nanoparticle system, in a process called theranostics. Metal nanoparticles can be synthesized to modulate their size and shape, and conjugated with different ligands, which allow their application in drug delivery, diagnostics, and treatment of central nervous system diseases. This review is focused on the potential applications of metal nanoparticles and their capability to circumvent the blood–brain barrier (BBB). Although many articles have demonstrated delivery of metal nanoparticles to the brain by crossing the BBB after systemic administration, the percentage of the injected dose that reaches this organ is low in comparison to others, especially the liver and spleen. In connection with this drawback, we elaborate the architecture of the BBB and review possible mechanisms to cross this barrier by engineered nanoparticles. The potential uses of metal nanoparticles for treatment of disorders as well as related neurotoxicological considerations are also discussed. Finally, we bring up for discussion a direct and relatively simpler solution to the problem. We discuss this in detail after having proposed the use of the intranasal administration route as a way to circumvent the BBB. This route has not been extensively studied yet for metal nanoparticles, although it could be used as a research tool for mechanistic understanding and toxicity as well as an added value for medical practice.

    AB - Metal nanoparticles have been proposed as a carrier and a therapeutic agent in biomedical field because of their unique physiochemical properties. Due to these physicochemical properties, they can be used in different fields of biomedicine. In relation to this, plasmonic nanoparticles can be used for detection and photothermal destruction of tumor cells or toxic protein aggregates, and magnetic iron nanoparticles can be used for imaging and for hyperthermia of tumor cells. In addition, both therapy and imaging can be combined in one nanoparticle system, in a process called theranostics. Metal nanoparticles can be synthesized to modulate their size and shape, and conjugated with different ligands, which allow their application in drug delivery, diagnostics, and treatment of central nervous system diseases. This review is focused on the potential applications of metal nanoparticles and their capability to circumvent the blood–brain barrier (BBB). Although many articles have demonstrated delivery of metal nanoparticles to the brain by crossing the BBB after systemic administration, the percentage of the injected dose that reaches this organ is low in comparison to others, especially the liver and spleen. In connection with this drawback, we elaborate the architecture of the BBB and review possible mechanisms to cross this barrier by engineered nanoparticles. The potential uses of metal nanoparticles for treatment of disorders as well as related neurotoxicological considerations are also discussed. Finally, we bring up for discussion a direct and relatively simpler solution to the problem. We discuss this in detail after having proposed the use of the intranasal administration route as a way to circumvent the BBB. This route has not been extensively studied yet for metal nanoparticles, although it could be used as a research tool for mechanistic understanding and toxicity as well as an added value for medical practice.

    KW - Gold nanoparticles

    KW - Intranasal route

    KW - Magnetic nanoparticles

    KW - Transcytosis

    UR - http://www.scopus.com/inward/record.url?scp=84994065458&partnerID=8YFLogxK

    U2 - 10.1016/bs.irn.2016.06.007

    DO - 10.1016/bs.irn.2016.06.007

    M3 - Chapter

    SN - 9780128046364

    VL - 130

    T3 - International Review of Neurobiology

    SP - 199

    EP - 227

    BT - Nanotechnology and the Brain, 2016

    PB - Academic Press Inc.

    ER -

    Sintov AC, Velasco-Aguirre C, Gallardo-Toledo E, Araya E, Kogan MJ. Metal Nanoparticles as Targeted Carriers Circumventing the Blood–Brain Barrier. En Nanotechnology and the Brain, 2016. Vol. 130. Academic Press Inc.2016. p. 199-227. (International Review of Neurobiology). Disponible desde, DOI: 10.1016/bs.irn.2016.06.007