Skeletal muscle wasting: new role of nonclassical renin–angiotensin system

Claudio Cabello-Verrugio, Juan C. Rivera, Dominga Garcia

Resultado de la investigación: Research - revisión exhaustivaArticle

Resumen

PURPOSE OF REVIEW: Skeletal muscle can be affected by many physiological and pathological conditions that contribute to the development of muscle weakness, including skeletal muscle loss, inflammatory processes, or fibrosis. Therefore, research into therapeutic treatment alternatives or alleviation of these effects on skeletal muscle is of great importance. RECENT FINDINGS: Recent studies have shown that angiotensin (1–7) [Ang-(1–7)] – a vasoactive peptide of the nonclassical axis in the renin–angiotensin system (RAS) – and its Mas receptor are expressed in skeletal muscle. Ang-(1–7), through its Mas receptor, prevents or diminishes deleterious effects induced by skeletal muscle disease or injury. Specifically, the Ang-(1–7)–Mas receptor axis modulates molecular mechanisms involved in muscle mass regulation, such as the ubiquitin proteasome pathway, the insulin-like growth factor type 1/Akt (protein kinase B) pathway, or myonuclear apoptosis, and also inflammation and fibrosis pathways. SUMMARY: Although further research into this topic and the possible side effects of Ang-(1–7) is necessary, these findings are promising, and suggest that the Ang-(1–7)–Mas axis can be considered a possible therapeutic target for treating patients with muscular disorders.

IdiomaEnglish
PublicaciónCurrent Opinion in Clinical Nutrition and Metabolic Care
DOI
EstadoAccepted/In press - 16 feb 2017

Huella dactilar

Renin-Angiotensin System
Skeletal Muscle
angiotensin I (1-7)
Fibrosis
Therapeutics
Therapeutic Human Experimentation
Proto-Oncogene Proteins c-akt
Muscle Weakness
Somatomedins
Proteasome Endopeptidase Complex
Ubiquitin
Apoptosis
Inflammation
Muscles
Peptides
Wounds and Injuries
Research

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Citar esto

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abstract = "PURPOSE OF REVIEW: Skeletal muscle can be affected by many physiological and pathological conditions that contribute to the development of muscle weakness, including skeletal muscle loss, inflammatory processes, or fibrosis. Therefore, research into therapeutic treatment alternatives or alleviation of these effects on skeletal muscle is of great importance. RECENT FINDINGS: Recent studies have shown that angiotensin (1–7) [Ang-(1–7)] – a vasoactive peptide of the nonclassical axis in the renin–angiotensin system (RAS) – and its Mas receptor are expressed in skeletal muscle. Ang-(1–7), through its Mas receptor, prevents or diminishes deleterious effects induced by skeletal muscle disease or injury. Specifically, the Ang-(1–7)–Mas receptor axis modulates molecular mechanisms involved in muscle mass regulation, such as the ubiquitin proteasome pathway, the insulin-like growth factor type 1/Akt (protein kinase B) pathway, or myonuclear apoptosis, and also inflammation and fibrosis pathways. SUMMARY: Although further research into this topic and the possible side effects of Ang-(1–7) is necessary, these findings are promising, and suggest that the Ang-(1–7)–Mas axis can be considered a possible therapeutic target for treating patients with muscular disorders.",
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Skeletal muscle wasting : new role of nonclassical renin–angiotensin system. / Cabello-Verrugio, Claudio; Rivera, Juan C.; Garcia, Dominga.

En: Current Opinion in Clinical Nutrition and Metabolic Care, 16.02.2017.

Resultado de la investigación: Research - revisión exhaustivaArticle

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